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The combination of ibrutinib and venetoclax has emerged as a promising therapeutic strategy for patients with chronic lymphocytic leukemia (cll). The combination of ibrutinib and venetoclax has been shown to improve outcomes in patients with chronic lymphocytic leukemia (cll) as compared with chemoimmunotherapy. Ibrutinib plus venetoclax is recommended as an option for untreated chronic lymphocytic leukaemia (cll) or small lymphocytic lymphoma (sll) in adults

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All the criteria as described in the appropriate blueteq form are met and an application for use has been approved. Ibrutinib plus venetoclax achieved higher undetectable mrd rates and extended pfs compared to ibrutinib alone or fcr in cll patients Retreatment with ibrutinib or acalabrutinib was effective for patients who experienced disease relapse.